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This scoping review aims to synthesize evidence on the relationship between maternal circulating miRNAs and infant birth weight outcomes.

June 21, 2026Epigenetics ReportsOpen Access

Circulating maternal MicroRNAs and infant birth weight: a scoping review

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Scoping review identifies associations between maternal microRNAs and birth weight, suggesting implications for neonatal health.

This scoping review aims to synthesize evidence on the relationship between maternal circulating miRNAs and infant birth weight outcomes.
Databases searched include Scopus, Web of Science, and MEDLINE-Pubmed for English articles until October 2025.
Among 284 records screened, 33 full texts assessed; 25 studies met inclusion criteria for review.
Identified 11 miRNAs with reported associations to birth weight in two or more studies.
Lower levels of miR-18a consistently associated with high birth weight (HBW).
miR-181a-5p found associated with low birth weight (LBW).
Existing studies show heterogeneity in associations, suggesting challenges in using miRNAs as reliable biomarkers.

Ahmed et al. (2026) studied this question.

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