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June 21, 2026Current HIV/AIDS ReportsOpen Access

HIV Reservoirs in Brain parenchyma and Cerebrospinal Fluid During Suppressive ART: Same-Same or Very Different?

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Authors

TAThomas A. AngelovichJEJanna Jamal EddineECEmily Chalmers

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Overview

Review describes HIV reservoirs in the CNS, highlighting implications for cognitive disorders and treatment strategies.

Key Points

  • This review aims to explore the characteristics and impact of HIV reservoirs in the CNS, particularly their role in cognitive disorders despite ART.
  • Review of current literature on HIV reservoirs in the CNS.
  • Analysis of intact and defective HIV proviral DNA in brain parenchyma and CSF.
  • Discussion of the implications of viral persistence on neuroinflammation and cognitive function.
  • Intact and defective HIV proviral DNA found in brain parenchyma and CSF of ART-suppressed individuals.
  • Active viral persistence likely increases the risk of neurocognitive issues and neuroinflammation.
  • Distinct characteristics of reservoirs in sub-regions of the CNS suggest different impacts on brain pathology.

Cite This Study

Angelovich et al. (2026) studied this question.

synapsesocial.com/papers/6a3781db24f042ddf4c5b784https://doi.org/10.1007/s11904-026-00790-3
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