Key result
Immune cell-derived exosomes facilitate post-MI myocardial repair and preserve ventricular function by modulating immune responses.
Why the study?
Excessive post-MI inflammation promotes abnormal cardiac remodelling, creating a need to evaluate how immune cell-derived exosomes modulate immune responses and repair damaged myocardium.
Immune cell-derived exosomes present a promising molecular target and potential cell-free therapeutic strategy to attenuate adverse remodeling and enhance cardiac repair following myocardial infarction.
Immune cell exosomes warrant investigation as cell-free therapy post-MI; leaves open translation beyond pre-clinical models.
After a myocardial infarction (MI), the inflammatory responses are induced and assist to repair ischaemic injury and restore tissue integrity, but excessive inflammatory processes promote abnormal cardiac remodelling and progress towards heart failure. Thus, a timely resolution of inflammation and a firmly regulated balance between regulatory and inflammatory mechanisms can be helpful. Molecular‐ and cellular‐based approaches modulating immune response post‐MI have emerged as a promising therapeutic strategy. Exosomes are essential mediators of cell‐to‐cell communications, which are effective in modulating immune responses and immune cells following MI, improving the repair process of infarcted myocardium and maintaining ventricular function via the crosstalk among immune cells or between immune cells and myocardial cells. The present review aimed to seek the role of immune cell‐secreted exosomes in infarcted myocardium post‐MI, together with mechanisms behind their repairing impact on the damaged myocardium. The exosomes we focus on are secreted by classic immune cells including macrophages, dendritic cells, regulatory T cells and CD4 + T cells; however, further research is demanded to determine the role of exosomes secreted by other immune cells, such as B cells, neutrophils and mast cells, in infarcted myocardium after MI. This knowledge can assist in the development of future therapeutic strategies, which may benefit MI patients.
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Wen et al. (2021) conducted a review in Myocardial infarction. Immune cell-derived exosomes was evaluated. Immune cell-derived exosomes modulate immune responses following myocardial infarction, facilitating the reparative process of infarcted myocardium and preserving ventricular function.
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