Key result
Higher postmenstrual age in healthy newborns is linked to lower cardiac troponin T levels.
Why the study?
What are the physiologic ranges of cardiac troponin T in healthy newborns and what factors influence them?
Cross-Sectional (n=59)
No
What are the physiologic ranges of cardiac troponin T in healthy newborns and what factors influence them?
Cardiac troponin T concentrations in healthy newborns depend on postmenstrual age but not on sex, delivery mode, or blood saturation, providing foundational data for its use as a diagnostic marker in this population.
Supports age-adjusted cTnT reference ranges in newborns; leaves open diagnostic utility pending prospective validation.
INTRODUCTION: In this paper, we evaluated the physiologic ranges of cardiac troponin T (cTnT) serum concentrations in healthy newborns. This is significant because these ranges have not been determined yet, especially for newborns older than 7 days. Cardiac troponins are widely used as diagnostic markers in adults; however, they cannot be routinely used in infants due to lack of data concerning normal values in this age group. AIM: To determine the physiologic ranges of cTnT concentrations in newborns and to evaluate the influence of factors such as age, sex, and blood saturation. METHODS: The study involved 59 newborns up to 46 weeks of postmenstrual age (full-term and preterm). The exclusion criteria were severe perinatal asphyxia and presence of severe diseases. Troponin T concentrations were evaluated by the Roche CARDIAC T Quantitative Test. The obtained results were statistically analyzed by the use of the Statistica 9.0 computer program. RESULTS: The study revealed that cTnT levels in newborns correlate with postmenstrual age, but not with chronologic or fetal age. Sex, delivery mode, and blood oxygenation did not influence cTnT concentrations in the studied patients. CONCLUSIONS: (1) Cardiac troponin T concentration depends on postmenstrual age in newborns. (2) Cardiac troponin T concentration in newborns does not depend on sex, mode of delivery, or blood saturation.
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Tarkowska et al. (2017) conducted a cross-sectional in Healthy newborns (n=59). Postmenstrual age was evaluated on Correlation between cardiac troponin T (cTnT) concentration and postmenstrual age (R = -0.319, p=0.027). In healthy newborns, cardiac troponin T concentrations showed a significant negative correlation with postmenstrual age (R = -0.319, p = 0.027), but not with sex, delivery mode, or blood oxygenation.
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