Key result
Abdominoplasty significantly reduced plasma concentrations of TNF-alpha and IL-6 and improved myocardial performance index compared with a hypocaloric diet at 2 months in obese women.
Why the study?
Does abdominoplasty improve myocardial performance index and reduce proinflammatory cytokines in premenopausal obese women compared to a hypocaloric diet?
Cohort (n=48)
Does abdominoplasty improve myocardial performance index and reduce proinflammatory cytokines in premenopausal obese women compared to a hypocaloric diet?
Surgical removal of subcutaneous abdominal fat via abdominoplasty improves echocardiographic markers of ventricular function and reduces systemic inflammation in premenopausal obese women.
Should not yet change practice in obese women; hypothesis-generating for surgical fat removal benefits beyond diet, pending RCTs.
The role of surgically removing subcutaneous fat by abdominoplasty on circulating inflammatory markers and myocardial dysfunction, evaluated by myocardial performance index (MPI), were investigated. Twenty volunteers submitted to the abdominoplasty (abdominoplasty group), and other 28 women treated by hypocaloric diet (diet group) were evaluated. Echocardiographic parameters of MPI, circulating levels of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, were performed at baseline and 2 months later. Compared with nonobese women, obese women had increased concentrations of TNF-alpha (P < 0.01), IL-6 (P < 0.01), and higher MPI (P < 0.02), indicating ventricular dysfunction. Subcutaneous fat concentrations of TNF-alpha and IL-6 were related to MPI impairment. After 60 days, waist-to hip ratio was significantly reduced in the abdominoplasty group. Anthropometric changes were accompanied by a significant decline in plasma concentrations of TNF-alpha and IL-6 levels as well as by significant improvements of MPI in abdominoplasty group compared with diet group. Abdominoplasty may represent a safe method for ameliorating cardiac function in obese women.
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Marfella et al. (2009) conducted a cohort in Obesity with ventricular dysfunction (n=48). Abdominoplasty vs. Hypocaloric diet was evaluated on Myocardial performance index (MPI) and circulating levels of TNF-alpha and IL-6. Abdominoplasty significantly reduced plasma concentrations of TNF-alpha and IL-6 and improved myocardial performance index compared with a hypocaloric diet at 2 months in obese women.
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