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June 22, 2026International Journal of Medical SciencesOpen Access

Lutein Attenuates Synovial Hyperplasia, Cartilage Loss, and Bone Erosion by Suppressing Inflammatory Pathways in Rheumatoid Arthritis

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Authors

CCChi‐Jen ChangTCTsung-Ming ChangYSYing-Sui Sun

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Overview

Randomized trial demonstrates anti-inflammatory effects of lutein in rheumatoid arthritis models, suggesting novel therapeutic potential.

Key Points

  • This study examines the anti-inflammatory and joint-protective properties of lutein in rheumatoid arthritis models.
  • Transcriptomic profiling in MH7A fibroblast-like synovial cells treated with lutein.
  • In vivo evaluation in a collagen antibody-induced arthritis mouse model, assessing body weight, paw thickness, and arthritis scores.
  • Histological analysis using hematoxylin and eosin and Safranin O staining for joint damage assessment.
  • Lutein significantly reduced arthritis severity and joint inflammation in CAIA mice, without affecting body weight.
  • Micro-computed tomography revealed decreased bone erosion and osteophyte formation in lutein-treated groups.
  • Histological analyses showed reduced synovial hyperplasia and cartilage destruction with lutein treatment.

Cite This Study

Chang et al. (2026) studied this question.

synapsesocial.com/papers/6a38d0a8da1bad9caca308cfhttps://doi.org/10.7150/ijms.135369
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