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June 22, 2026Scientific ReportsOpen Access

Designing of a conserved subunit multiepitope vaccine candidate against Francisella tularensis Schu S4 using immunoinformatics

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Authors

SASheikh Sunzid AhmedUniversity of DhakaMRM Oliur RahmanUniversity of DhakaMBMiruna BanuUniversity of Dhaka

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Implication

Randomized trial evaluates multi-epitope vaccine candidates for tularemia, suggesting potential for effective prevention.

Key Points

  • This research aims to design a conserved subunit multi-epitope vaccine candidate against Francisella tularensis Schu S4.
  • Utilized immunoinformatics to identify B- and T-cell epitopes targeting virulence factors DacD and DsbA.
  • Modeled and validated vaccine candidates through molecular docking and molecular dynamics simulations.
  • Evaluated immunogenic potential via immune simulations and cloned constructs into expression vector pET30a( +).
  • TulaVac1 and TulaVac2 exhibited high antigenicity and immunogenicity with nearly 100% epitope conservancy.
  • Global population coverage rates were 73.19% for MHC class I and 99.74% for MHC class II epitopes.
  • Molecular docking revealed high binding energies (≤ -9.0 kcal/mol) indicating strong interactions with TLRs and MHC.

Cite This Study

Ahmed et al. (2026) studied this question.

synapsesocial.com/papers/6a38d0a8da1bad9caca3099fhttps://doi.org/10.1038/s41598-026-58834-y
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