An Experimental Study to Evaluate the Efficacy of Laksha Guggulu on Fracture Healing in Oryctolagus Cuniculus

Export Introduction: The prevalence of skeletal injuries is continuously on the rise owing to the reckless lifestyle, increased vehicular load on the roads, day-by-day increasing incidences of violence due to one reason or another, and many such reasons. An increase in the volume of the elderly population associated with senile osteoporosis is also a major factor responsible for the increased incidence of fractures in the elderly population. This is the high time to merge the conventional fundamentals of Ayurveda and contemporary science to have an effective outcome to face the challenges concerning fracture management like delayed healing and nonunion and postimmobilization-induced stiffness. Methods: In the present study, a total of 21 rabbits (Oryctolagus cuniculus) were used in the trial for 4 weeks. The left radial mid-diaphysis was selected for the open transverse osteotomy. The animals were divided into three groups of seven animals in each group. Group I was control group while Group II (Trial drug Laksha Guggulu 400 mg/kg by body weight) and Group III (Trial drug Laksha Guggulu 600 mg/kg by body weight) were the treated groups. Statistical analyses of the observations and results have been made using the appropriate tools to conclude the study. Results and Conclusion: The trial drug Laksha Guggulu in the dose of 600 mg/kg has given a better outcome when assessed through radiological valuation using XRS and XRG parameters, serum bone-specific alkaline phosphatase, serum osteocalcin, histomorphometry using micro-computed tomography, and histopathologic grade (HPG) against the tested dose of 400 mg/kg and control.