Key result
MIS-C presents with distinct hematologic markers and cardiac complications compared to Kawasaki disease.
Why the study?
MIS-C exhibits overlapping symptoms with Kawasaki Disease, with both associated with vascular inflammation and cardiac complications, prompting a comparison of their laboratory findings and cardiac complications.
What are the differences in laboratory findings and cardiac complications between children with Kawasaki Disease and Multisystem Inflammatory Syndrome?
Observational (n=115)
What are the differences in laboratory findings and cardiac complications between children with Kawasaki Disease and Multisystem Inflammatory Syndrome?
p-value: p=<0.05
While MIS-C and Kawasaki Disease share overlapping features, they exhibit significant differences in specific hematological markers and echocardiographic findings such as pericardial effusion and vascular ectasia.
May aid differentiation of MIS-C from Kawasaki disease; hypothesis-generating and requires prospective validation before clinical use.
Background and Aim: One phenomenon observed during the COVID-19 pandemic is the emergence of multisystem inflammatory syndrome in children (MIS-C).Patients with this condition exhibit overlapping symptoms with those of Kawasaki Disease (KD).Both KD and MIS are pathological conditions associated with vascular inflammation and cardiac complications.This study aimed to assess and compare laboratory findings and cardiac complications in children diagnosed with both conditions. Materials and Methods:After the clinical diagnosis of MIS-C and KD, demographic, clinical, laboratory, and echocardiographic data were entered into a checklist for evaluation.All data were entered into SPSS software, version 26 and analyzed using t-test and chi-square tests.A significance level of 0.05 was considered for all tests.Results: A total of 115 patients were included in this study.Among these, 92 patients were in the MIS-C group and 24 were in the Kawasaki group.No statistically significant differences were found between the two groups concerning age, sex, thrombocytopenia, and fibrinogen levels (P>0.05).However, statistically significant differences were observed between the two groups regarding white blood cell counts, lymphopenia, platelets, hemoglobin, erythrocyte sedimentation rate (ESR), cardiac output, pericardial effusion, vascular ectasia, and mild mitral regurgitation (MR) (P<0.05).No statistically significant differences were noted in moderate-tosevere vascular aneurysms and moderate tricuspid regurgitation (TR) between the two groups (P>0.05). Conclusion:Early diagnosis and proper management of cardiac complications in children with KD and MIS-C are essential to prevent long-term complications.Further studies are required to deepen our understanding of these two clinical conditions' disease mechanisms and cardiac complications.
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Arjmandnia et al. (2025) conducted an observational in Kawasaki Disease and Multisystem Inflammatory Syndrome in Children (MIS-C) (n=115). Multisystem Inflammatory Syndrome in Children (MIS-C) vs. Kawasaki Disease (KD) was evaluated on Laboratory findings and cardiac complications (p=<0.05). Children with MIS-C exhibited significant differences in white blood cell counts, platelets, hemoglobin, ESR, and specific cardiac complications compared to those with Kawasaki Disease (P<0.05).
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