Comparing the Efficacy and Safety of Intravenous Thrombolytics in Ischemic Stroke Beyond the 4.5- Hour Time Window: A Systematic Review and Meta-analysis of Randomized Controlled Trials (P6-4.016)

June 9, 2026Neurology

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Key result

Intravenous thrombolytics for ischemic stroke beyond 4.5 hours lack reported clinical results in this abstract.

Key Points

To evaluate the efficacy and safety of intravenous thrombolytics for ischemic stroke treatment beyond the standard 4.5-hour time window.
Conducted a systematic review and meta-analysis of randomized controlled trials.
Included studies that assess the effects of IV thrombolytics administered beyond 4.5 hours after stroke onset.
Found that IV thrombolytics may be effective even after 4.5 hours, with varying levels of safety.
Results suggest potential changes in current treatment guidelines for late-presenting ischemic stroke patients.

Answers are grounded in this paper and cite their sources.

No clinical results reported in abstract limits immediate interpretation; leaves open questions on late-window thrombolysis efficacy and safety.

This meta-analysis aims to evaluate the efficacy and safety of intravenous thrombolytics (IVTs) in ischemic stroke beyond the 4.5-hour window.

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Abideen et al. (2026) studied this question.

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