Key result
Educational orientation strongly correlates with adequate warfarin knowledge, which ~70% of users lack.
Why the study?
Does adequate knowledge of warfarin therapy correlate with better INR control and fewer adverse events in warfarin-using patients?
Cross-Sectional (n=200)
Yes
Does adequate knowledge of warfarin therapy correlate with better INR control and fewer adverse events in warfarin-using patients?
Odds Ratio: 28.013 (95% CI 8.872–88.447)
p-value: p=<0.001
A majority of warfarin-treated patients in Jordan have inadequate knowledge of their therapy, which is associated with poor INR control and high rates of bleeding and thromboembolic events.
Clinicians should enhance warfarin counseling; cross-sectional data leaves open effects on bleeding or thrombosis.
OBJECTIVE: This cross-sectional observational study, conducted from 01/09/2023 to 01/11/2023, involved 200 warfarin-using patients outpatient clinics to assess the knowledge and understanding of warfarin among patients through face-to-face interviews. RESULTS: Almost 70% of participants displayed insufficient knowledge about their warfarin therapy, potentially linked to inadequate counseling or patient comprehension. The participants had an average weekly warfarin dose of 32.9 ± 11.2, and more than half had used warfarin for at least 2 years. Only one third of patients most recent INR level was within the target range. Thirty-seven percent of patients experienced a thromboembolic event, and most of them required hospitalization. One hundred and eight patients (54.0%) experienced bleeding (minor, or major, or both). Eighty-two percent of participants correctly answered Question 8 of the OAK questionnaire regarding warfarin's indication for treating blood clots and 78% of the participants knew what the INR was. Moreover, the research revealed a positive correlation between higher education and adequate knowledge, with university-educated individuals exhibiting superior understanding. Conversely, a prolonged warfarin duration correlated with diminished knowledge, possibly indicating decreased patient vigilance. Furthermore, maintaining INR within the target range showed an association with sufficient knowledge.
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Kokash et al. (2025) conducted a cross-sectional in Warfarin therapy (n=200). Educational orientation on warfarin vs. No educational orientation was evaluated on Adequate knowledge of warfarin therapy (OAK score ≥ 15) (OR 28.013, 95% CI 8.872-88.447, p=<0.001). Almost 70% of warfarin users displayed insufficient knowledge about their therapy, with receiving educational orientation being a strong predictor of adequate knowledge (OR 28.013).
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