Why the study?
It remained unclear which body size variable normalizes left ventricular mass without underestimating it in overweight children.
Does normalization for body surface area or computed lean body mass underestimate left ventricular mass in overweight children compared to normalization for height?
Population
464 healthy boys, 5-18 years old
Comparison
Overweight vs non-overweight children across different normalization variables
Design
Cross-sectional study
Key result
Normalization for body surface area underestimates left ventricular mass in overweight children compared to non-overweight children (mean z-score -0.64 vs 0.00), whereas height does not.
Authors
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May warrant caution with BSA-based LVM norms in overweight youth; leaves open optimal indexing for pediatric studies.
Cross-Sectional (n=464)
Does normalization for body surface area or computed lean body mass underestimate left ventricular mass in overweight children compared to normalization for height?
Absolute Event Rate: -0.64% vs 0%
Normalization of left ventricular mass for body surface area or computed lean body mass underestimates left ventricular mass in overweight children, suggesting height is a more appropriate normalizing variable.
Krysztofiak et al. (2019) conducted a cross-sectional in Overweight (n=464). Overweight status vs. Non-overweight status was evaluated on Mean left ventricular mass z-score based on body surface area. Normalization for body surface area underestimates left ventricular mass in overweight children compared to non-overweight children (mean z-score -0.64 vs 0.00), whereas height does not.