Key result
Electrophysiology simulations using individual transmural fiber interpolation functions predicted consistent maximum local activation times, suggesting a negligible effect of the transmural myofiber architecture on the activation pattern.
A novel automated modeling pipeline successfully generated personalized left atrial computational models, demonstrating that transmural myofiber architecture has a negligible effect on local activation times in electrophysiology simulations.
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CT-based atrial models may refine AF substrate assessment; hypothesis-generating and requires prospective validation before clinical use.
Fastl et al. (2018) studied Atrial fibrillation (modeling context) (n=3). Anisotropic electrophysiology simulations with variable transmural fiber interpolation functions vs. Isotropic reference simulation was evaluated on Maximum local activation time (LAT). Electrophysiology simulations using individual transmural fiber interpolation functions predicted consistent maximum local activation times, suggesting a negligible effect of the transmural myofiber architecture on the activation pattern.
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