Key result
Patients with atrial fibrillation had significantly thicker pulmonary vein-left atrial junction walls compared to controls (0.88 vs. 0.65 mm, P<0.0001), which was independently associated with AF.
Why the study?
Is left atrial and PV-LA junction wall thickness associated with atrial fibrillation, electrogram characteristics, and ATP-provoked dormant PV conduction?
Population
75 patients, comprising 50 patients with atrial fibrillation (AF) and 25 patients without AF (control group).
Comparison
Measurement of left atrial and pulmonary vein-LA… vs Patients without AF.
Design
Cross-sectional
Authors
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Thicker LA/PV-LA walls associate with AF remodeling and dormant conduction; leaves open whether thickness informs ablation strategy.
Case-Control (n=75)
Is left atrial and PV-LA junction wall thickness associated with atrial fibrillation, electrogram characteristics, and ATP-provoked dormant PV conduction?
Effect estimate: β = 0.40
Absolute Event Rate: 0.88% vs 0.65%
p-value: p=<0.0001
Thickened PV-LA junction walls are associated with atrial fibrillation, increased bipolar voltage, and ATP-provoked dormant PV conduction, suggesting a structural basis for AF maintenance and ablation outcomes.
Takahashi et al. (2015) conducted a case-control in Atrial Fibrillation (n=75). Atrial fibrillation vs. Patients without atrial fibrillation was evaluated on Wall thickness of the pulmonary vein-left atrial (PV-LA) junction (β = 0.40, p=<0.0001). Patients with atrial fibrillation had significantly thicker pulmonary vein-left atrial junction walls compared to controls (0.88 vs. 0.65 mm, P<0.0001), which was independently associated with AF.
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