Comparative Effects of Two High-intensity Training Modes With Curcumin on Nuclear Factor Kappa B

Background and Aim: Type 2 diabetes is associated with increased activation of inflammatory pathways, such as nuclear factor kappa B (NF-κB), which can negatively affect cardiac function.This study aimed to investigate the effect of two types of 4-week high-intensity interval training (HIIT) combined with curcumin supplementation on NF-κB protein levels in the left ventricle of rats with type 2 diabetes. Materials and Methods:In this experimental study, 49 male diabetic rats were randomly assigned to seven groups (n=7 per group): Normal control, diabetic control, supplemented, HIIT1, HIIT2, supplemented HIIT1, and supplemented HIIT2.The HIIT protocols were performed five days a week for four weeks.Curcumin was administered orally at 100 mg/kg body weight daily.NF-κB protein levels were measured using the Western blot technique.Data were analyzed using two-way analysis of variance (ANOVA) with a significance level set at P<0.05. Results:The results showed a significant increase in NF-κB protein levels in the diabetic control group compared to all other groups.However, NF-κB levels significantly decreased in the supplemented, HIIT1, HIIT2, supplemented HIIT1, and supplemented HIIT2 groups.Moreover, a significantly greater reduction in NF-κB levels was observed in the supplemented HIIT2 group compared to the supplemented HIIT1 group. Conclusion:Overall, the findings suggest a potentially greater effect of curcumin supplementation combined with the HIIT2 in modulating NF-κB protein expression.