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May 19, 2023Frontiers in EndocrinologyOpen Access

HIIT significantly reduced pathological hypertrophy, fibrosis, and cardiomyocyte apoptosis, decreased B-catenin and c-Myc protein levels, and increased GSK3B and Bcl-2 protein levels in diabetic rats.

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Why the study?

Type 2 diabetes is a major risk factor for cardiovascular disorders, prompting the need to reduce and manage diabetes-related cardiovascular disease.

Does high-intensity interval training improve histopathological and molecular indices of cardiomyopathy in type 2 diabetic rats?

Population

Rats divided into 4 groups of n=8 each (Healthy Control, Diabetes Control, Diabetes Training, Healthy Training)

Comparison

High-intensity interval training vs control

Design

Preclinical animal study

Follow-up

8 weeks

Authors

MRMohammad RamiSRSamane RahdarAHAmirhoseein Ahmadi Hekmatikar

Discussion

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Member takes

Overview

HIIT reduced cardiac fibrosis in diabetic rats; leaves open whether benefits extend to human type 2 diabetes cardiomyopathy.

Structured PICO

Does high-intensity interval training improve histopathological and molecular indices of cardiomyopathy in type 2 diabetic rats?

P
Population
Type 2 diabetic rats and healthy rats (n=32 total, divided into 4 groups: Healthy Control n=8, Diabetes Control n=8, Diabetes Training n=8, and Healthy Training n=8)
I
Intervention
8 weeks of High-intensity interval training (HIIT), 5 sessions per week, starting at 80% of peak speed in the first week with 10% added every week
C
Comparator
Diabetes Control (no training) and Healthy Control
O
Outcome
Cardiac pathological changes (hypertrophy, fibrosis, apoptosis) and molecular indices (levels of B-catenin, c-MYC, GSK3B, and Bcl-2 proteins)surrogate

High-intensity interval training may be an effective strategy to attenuate cardiomyopathy and adverse molecular remodeling in type 2 diabetes.

Cite This Study

Rami et al. (2023) studied this question.

synapsesocial.com/papers/6a7561920b1b00a0ee093180https://doi.org/10.3389/fendo.2023.1175585
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