Key result
An 8-week High-Intensity Interval Training program did not significantly reduce serum Cardiac troponin I levels in diabetic rats compared to untrained diabetic controls (11% reduction, P=0.591).
Why the study?
Cardiovascular complications are a major concern in diabetes, and the effect of high-intensity interval training on serum cardiac troponin I levels in diabetic subjects is unclear.
Does an eight-week HIIT program reduce serum CtnI and blood glucose levels in streptozotocin-induced diabetic rats?
RCT (n=30)
randomly assigned
Does an eight-week HIIT program reduce serum CtnI and blood glucose levels in streptozotocin-induced diabetic rats?
Answers are grounded in this paper and cite their sources.
An 8-week HIIT program significantly reduced fasting blood glucose but did not significantly reduce serum cardiac troponin I levels in a rat model of diabetes.
Background: One of the complications of diabetes, as a chronic metabolic disorder, is cardiovascular diseases. Objective This study aims to investigate the effect of an eight-week High-Intensity Interval Training (HIIT) program on serum Cardiac troponin I (CtnI) level in streptozotocin-induced diabetic rats. Methods: In this experimental clinical trial, 30 rats were randomly assigned into three groups of healthy Control (C), Diabetic (D), and diabetic+training (D+T). The third group performed the training which included a treadmill running at an intensity of 85%-90% of maximum speed in 6-12 sessions of 2 min for 8 weeks, 5 days per week. Blood glucose level and high-sensitive CtnI levels were measured 48 hours after the last training session and 12 hours of fasting. One-way ANOVA and Tukey’s test were used to analyze the collected data, considering a significance level of P<0.05. Findings: The induction of diabetes caused a significant increase in blood glucose (P=0.01) and high-sensitive CtnI (P=0.01) levels in the D group. Also, a significant difference was observed in the blood glucose level of D+T group compared to the D group (P=0.001). The CtnI level also slightly reduced (11%) in the D+T group compared to the D group, but it was not statistically significant (P=0.591). Conclusion: he HIIT program can reduce the fasting blood glucose and increase the serum level of high-sensitive CtnI to some extent in diabetic rats; therefore, it can be an appropriate strategy for diabetics. However, there is a need for more studies in this area.
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Miraghaee et al. (2020) conducted an RCT in streptozotocin-induced diabetes (n=30). High-Intensity Interval Training (HIIT) vs. No training (Diabetic group) was evaluated on serum Cardiac troponin I (CtnI) level (p=0.591). An 8-week High-Intensity Interval Training program did not significantly reduce serum Cardiac troponin I levels in diabetic rats compared to untrained diabetic controls (11% reduction, P=0.591).
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