Key result
Four weeks of HIIT enhances cardiac RyR2 mRNA expression in diabetic rats versus sedentary controls.
Why the study?
Does 4-week HIIT improve myocardial expression of RyR2 and SERCA2a in STZ-induced diabetic rats?
Does 4-week HIIT improve myocardial expression of RyR2 and SERCA2a in STZ-induced diabetic rats?
A 4-week high-intensity interval training program significantly increased myocardial RyR2 gene expression in a rat model of STZ-induced diabetes.
Supports preclinical HIIT research on calcium handling in diabetic models; leaves open any human translation.
Background: To date, not sufficient information is available regarding the effect of High Intensity Interval Training (HIIT) on diabetes-induced myocardial dysfunctions.Objectives: The present study aimed to evaluate the effect of 4-week HIIT on change in expression levels of ryanodine receptor calcium channel (RyR2) and ATPase calcium pump (SERCA2a) in diabetic rats. Materials and Methods:This study was conducted on 24 Wistar rats with average weight of 245 ± 10 g.The rats were randomly divided into a sedentary diabetic group and a trained diabetic group.Training was started two weeks after diabetes induction by Streptozotocin (STZ) injection.The training program consisted of 4 weeks running on a treadmill and was considered to be intense for the two groups' diabetic rats.After all, the animals' characteristics and myocardial gene expression were compared using independent t-test.Results: Measurement of gene expression by Real Time-PCR revealed that cardiac mRNA expression of RyR2 was enhanced in the HIIT group.The results also revealed a significant (P = 0.03) difference between the hearts of the sedentary controls and the trained group regarding RyR2 levels.However, no significant difference was observed between the two groups with respect to SERCA2a levels (P = 0.14). Conclusions:The study results showed that treatment with HIIT could prevent and/or minimize the loss in expression of RyR2 and SERCA2a.
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Bigi et al. (2016) studied STZ-induced diabetes (n=24). High Intensity Interval Training (HIIT) vs. Sedentary diabetic control was evaluated on Cardiac mRNA expression of RyR2 (p=0.03). Four weeks of high intensity interval training significantly enhanced cardiac mRNA expression of RyR2 (P = 0.03) in rats with STZ-induced diabetes compared to sedentary controls.
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