Why the study?
Does exercise training improve cardiac ryanodine receptor function and cardiac function in a rat model of type 1 diabetes?
Population
Male Sprague-Dawley rats with streptozotocin (STZ)-induced type 1 diabetes
Comparison
Exercise training for 4 weeks, initiated 3 weeks… vs Sedentary diabetic rats
Design
Preclinical
Follow-up
4 weeks
Authors
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Supports exercise effects on RyR2 in diabetic rat models; leaves open translation to human type 1 diabetes.
Does exercise training improve cardiac ryanodine receptor function and cardiac function in a rat model of type 1 diabetes?
Exercise training during diabetes normalizes cardiac ryanodine receptor function and calcium release, providing a mechanism for improved cardiac function.
Shao et al. (2009) studied this question.
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