Key result
Exercise training prevented the development of diabetic cardiomyopathy and the dysregulation of sarcoplasmic reticulum protein content in an inducible rat model of type 2 diabetes.
Why the study?
Does exercise training prevent the development of cardiac dysfunction in a diabetic rat model?
Does exercise training prevent the development of cardiac dysfunction in a diabetic rat model?
Exercise training prevents the development of diabetic cardiomyopathy and dysregulation of sarcoplasmic reticulum proteins in a rat model of type 2 diabetes.
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Does not support clinical adoption in diabetic cardiomyopathy; leaves open translation of exercise effects from rat models to human prevention.
Epp et al. (2012) studied Diabetes-induced cardiac dysfunction. Exercise training (voluntary wheel running) vs. Sedentary group was evaluated on Diastolic function and SERCA2a protein content and activity. Exercise training prevented the development of diabetic cardiomyopathy and the dysregulation of sarcoplasmic reticulum protein content in an inducible rat model of type 2 diabetes.
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