January 1, 1995Journal of Applied Physiology
Exercise training attenuates the reduction in myocardial GLUT-4 in diabetic rats
Why the study?
Does moderate-intensity exercise training attenuate the reduction in myocardial GLUT-4 and GLUT-1 proteins in streptozotocin-induced diabetic rats?
Population
52 Sprague-Dawley rats, including streptozotocin-induced (65 mg/kg) diabetic and non-diabetic controls.
Comparison
Moderate-intensity exercise training for 10-12… vs Sedentary lifestyle (no exercise training).
Design
Preclinical, randomly divided
Follow-up
10-12 weeks
Authors
Discussion
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Implication
Should not change clinical practice; hypothesis-generating for exercise effects on myocardial glucose transport in diabetes.
Structured PICO
Does moderate-intensity exercise training attenuate the reduction in myocardial GLUT-4 and GLUT-1 proteins in streptozotocin-induced diabetic rats?
P
Population
52 Sprague-Dawley rats, including streptozotocin-induced (65 mg/kg) diabetic and non-diabetic controls.
I
Intervention
Moderate-intensity exercise training for 10-12 weeks.
C
Comparator
Sedentary lifestyle (no exercise training).
O
Outcome
Total myocardial GLUT-4 and GLUT-1 proteins.surrogate
Moderate-intensity exercise training partially preserves myocardial GLUT-4 protein levels and improves fasting blood glucose in a rat model of streptozotocin-induced diabetes.
Cite This Study
Hall et al. (1995) studied this question.