Why the study?
Does dynamic exercise training increase sarcolemmal GLUT-4 protein and mRNA content in the hearts of diabetic rats?
Population
Diabetic rats (diabetes induced by intravenous streptozotocin 60 mg/kg) and control rats
Comparison
Dynamic exercise training vs Sedentary control and sedentary diabetic rats
Design
Preclinical
Follow-up
10 weeks
Authors
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Exercise training may mitigate cardiac GLUT-4 loss in diabetic rat models; leaves open human translation and clinical practice change.
Does dynamic exercise training increase sarcolemmal GLUT-4 protein and mRNA content in the hearts of diabetic rats?
Exercise training partially restores sarcolemmal GLUT-4 protein and normalizes GLUT-4 mRNA levels in the diabetic rat heart, which may beneficially enhance myocardial glucose oxidation.
Osborn et al. (1997) studied this question.
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