Key result
Aerobic interval training almost completely restored the contractile function and Ca2+ handling of diabetic cardiomyocytes to levels close to sedentary wild type mice.
Why the study?
Does 13 weeks of aerobic interval training improve cardiomyocyte Ca2+ cycling and excitation-contraction coupling in a mouse model of type-2 diabetes?
Does 13 weeks of aerobic interval training improve cardiomyocyte Ca2+ cycling and excitation-contraction coupling in a mouse model of type-2 diabetes?
Aerobic interval training normalizes cardiomyocyte contractile function and calcium handling in diabetic mice without altering systemic glucose or insulin levels.
No takes yet. Share an insight, caveat, or question.
Should not yet change clinical practice in diabetes; leaves open human translation of cardiomyocyte benefits.
Stølen et al. (2009) studied Diabetic cardiomyopathy in type-2 diabetes (db/db) mice. Aerobic interval training vs. Sedentary db/db mice was evaluated on Cardiomyocyte contractile function and Ca2+ cycling. Aerobic interval training almost completely restored the contractile function and Ca2+ handling of diabetic cardiomyocytes to levels close to sedentary wild type mice.
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