Key result
Streptozotocin-induced diabetes in rats depressed peak stress compared to controls (10 vs 17 mN/mm2; P<0.05), with findings suggesting LV remodeling rather than altered calcium homeostasis is responsible.
Absolute Event Rate: 10% vs 17%
p-value: p=<0.05
In a rat model of diabetic cardiomyopathy, the contractile deficit is not driven by altered calcium homeostasis, but rather may be due to left ventricular remodeling such as increased collagen and reduced F-actin.
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May implicate LV remodeling in diabetic cardiomyopathy; hypothesis-generating and should not change practice.
Zhang et al. (2008) studied Diabetic cardiomyopathy. Streptozotocin-induced diabetes vs. Age-matched siblings (controls) was evaluated on Peak stress (p=<0.05). Streptozotocin-induced diabetes in rats depressed peak stress compared to controls (10 vs 17 mN/mm2; P<0.05), with findings suggesting LV remodeling rather than altered calcium homeostasis is responsible.
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