Population
Enzymically isolated rat ventricular myocytes from streptozotocin-induced diabetic rats and normal rats
Comparison
Streptozotocin-induced diabetes model vs Normal rat ventricular myocytes
Design
Preclinical
Authors
Loading...
May underlie diabetic cardiomyopathy via SR Ca2+ defects; leaves open human relevance and therapeutic targets.
Streptozotocin-induced diabetes in rats alters intracellular Ca2+ homeostasis in ventricular myocytes, primarily due to sarcoplasmic reticulum dysfunction, which may contribute to the development of diabetic cardiomyopathy.
Lagadic‐Gossmann et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: