Why the study?
Does streptozotocin-induced diabetes alter intracellular Ca2+ transients and contractile responses in rat cardiomyocytes?
Population
Left ventricular cardiomyocytes isolated from the hearts of control and streptozotocin-induced diabetic rats
Comparison
Steady state and transient changes in stimulus… vs Cardiomyocytes from control rats
Design
Preclinical
Authors
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No immediate clinical implications; extends consensus on frequency-dependent Ca2+ defects in diabetic rat models.
Does streptozotocin-induced diabetes alter intracellular Ca2+ transients and contractile responses in rat cardiomyocytes?
Diabetic rat cardiomyocytes exhibit a blunted frequency response and slower recovery of SR Ca2+ release, consistent with reduced SR Ca2+ uptake.
George Kotsanas (2000) studied this question.
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