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August 9, 2026BiomoleculesOpen Access

Non-Work-Matched HIIT and MIIT Partially Restore Exerkine-Related and Mitochondrial Gene Expression in Diabetic Rat Skeletal Muscle

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Authors

SRSaeed RezaeFerdowsi University of MashhadPMPayam Abasian MehrFerdowsi University of MashhadPPParisa PournematiUniversity of Tehran

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Overview

Randomized trial shows that interval training improves metabolic health in diabetic rats, suggesting potential therapeutic benefits.

Key Points

  • This research investigates how non-work-matched HIIT and MIIT affect gene expression related to insulin resistance in diabetic rats.
  • Twenty-four male Wistar rats were assigned to control, diabetic control, MIIT, or HIIT groups and trained for 6 weeks.
  • MIIT was performed at 70% maximal speed and HIIT at 90% maximal speed, with assessments of gene expression and metabolic indices post-training.
  • Gene expression of FNDC5, OSTN, PGC-1α, TFAM, CCO, and UCP3 was quantified using RT-qPCR.
  • Both MIIT and HIIT partially restored myokine- and mitochondrial-related gene expression compared to diabetic controls.
  • HIIT showed lower fasting insulin and HOMA-IR than MIIT, despite a greater cumulative workload tied to HIIT.

Cite This Study

Rezae et al. (2026) studied this question.

synapsesocial.com/papers/6a782d7b2e1896536c8409a3https://doi.org/10.3390/biom16081152
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