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April 27, 2026Biological ResearchOpen Access

Effects of MICT and HIIT on mitochondrial dynamics-related proteins in visceral adipose tissue of type 2 diabetic rats

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Authors

RRRahman RahimiUniversity of KurdistanIDIan G. DaviesLiverpool John Moores UniversityHGHadi GolpasandiUniversity of Kurdistan

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Implication

Randomized trial examines exercise effects on mitochondrial proteins in diabetic rats, suggesting potential metabolic benefits.

Key Points

  • This study aims to assess the impact of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on mitochondrial dynamics in type 2 diabetic rats.
  • Male Wistar rats (n = 40) induced with type 2 diabetes after high-fat diet and streptozotocin exposure.
  • Rats randomly allocated into diabetic control, MICT, and HIIT groups with exercise interventions lasting 8 weeks.
  • Protein levels in visceral adipose tissue were analyzed using Western blot techniques.
  • MICT reduced Drp-1 by 53.55% and Fis-1 by 16.08%; HIIT reduced Drp-1 by 77.81% and Fis-1 by 36.18% compared to diabetic controls.
  • Both exercise types increased MFN-2 (MICT: 26.25%, HIIT: 57.50%) and OPA-1 (MICT: 66.10%, HIIT: 103.39%) compared to controls.
  • Fasting serum glucose and HOMA-IR were significantly lower in both exercise groups (p < 0.001).

Cite This Study

Rahimi et al. (2026) studied this question.

synapsesocial.com/papers/69eefc6dfede9185760d36aahttps://doi.org/10.1186/s40659-026-00694-x
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Also Consider

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