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June 23, 2026Journal of Biomedical Materials Research Part B Applied Biomaterials

Strut Thickness and Species‐Specific Healing Are Key Considerations in Developing Zinc‐Based Biodegradable Arterial Stents

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Authors

LMLea M. MorathSRShebeer A. RahimCBCole A. Baker

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Overview

Randomized trial examines healing responses in biodegradable zinc stents, indicating model selection is crucial.

Key Points

  • This research aims to evaluate the performance and healing responses of different zinc-based biodegradable stents.
  • Examined three zinc-based alloys: AMZ, ACMZ, and CMM, focusing on strut thickness and processing.
  • Conducted in vivo implantation in abdominal aortas of mice and rats to analyze immune responses.
  • Assessed thrombogenicity and hemocompatibility through in vitro assays and ex vivo analyses.
  • Mice showed significant inflammation and necrosis, indicating poor biocompatibility (p<0.05).
  • Rats had minimal inflammation and reduced neointimal growth with 0.12 mm struts compared to 0.25 mm implants.
  • In vitro assays demonstrated low thrombogenicity with lower fibrin generation (p<0.01 compared to controls).

Cite This Study

Morath et al. (2026) studied this question.

synapsesocial.com/papers/6a3a21f3111626ef22ab6969https://doi.org/10.1002/jbm.b.70104
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