SFL-LS-05: Unified Quantification of Lifespan Atrophy Across Degenerative & Malignant Chronic Diseases

Integrating the lifespan formula L = Tavg × N and the full spectrum of cellular lesions recorded in SFL-CELL-02 to SFL-CELL-05, this paper establishes a universal quantitative standard to calculate lifespan loss brought by tumors, ALS, Parkinson’s disease and Alzheimer’s disease. All these illnesses share identical core logic: irreversible ΔGd(-) destruction of specific cell G₀ functional modules triggers mass premature cell rupture, suppresses systemic Tavg and speeds up the exhaustion of fixed renewal quota N. Malignant tumors arise from broken proliferation-limiting G₀ modules, creating endless abnormal cell division; ALS originates from collapsing axon repair modules of motor neurons; Parkinson’s and Alzheimer’s disease stem from impaired protein clearance modules in neural cells. Each pathological state generates persistent systemic micro-injury and abnormal cell turnover, dragging down the whole-body average functional cycle. Using the unified baseline N=10 for comparison: healthy humans hold Tavg=8 with baseline lifespan 80 years. Patients with moderate neurodegeneration or early cancer show Tavg dropping to 5 years (theoretical lifespan 50 years); severe late-stage cases may push Tavg as low as 3 years, only 30 years of predicted lifespan left. Traditional clinical treatments only eliminate superficial lesions (tumors, protein plaques, nerve inflammatory response) without restoring damaged native G₀ architecture, so they cannot reverse the low Tavg state and stop fast consumption of renewal quota. Fundamental intervention aims to reduce cumulative ΔGd(-), repair cell G₀ integrity, raise Tavg and slow quota depletion. This paper unifies all major chronic disorders into one quantitative aging evaluation system, perfectly matching the “repair decline spectrum” concept from SFL-CELL-06, realizing the organic combination of qualitative cellular pathology and quantitative lifespan calculation.