What question did this study set out to answer?

The aim is to explore the relationship between MRI radiomic features and key genetic markers related to IDH mutations in glioma.

June 23, 2026Cancer Cell InternationalOpen Access

Integrating MRI radiomics and transcriptomics to predict IDH mutation status and prognosis in glioma

View Full Paper

Ask AI

Bookmark

Authors

RZRong-De ZhongShenzhen University QLQi LiNanfang Hospital HWH WangSouthern University of Science and Technology

Discussion

Member takes

Implication

Randomized trial investigates MRI features and gene expression for predicting IDH mutations and glioma prognosis, indicating potential for personalized treatment.

Key Points

The aim is to explore the relationship between MRI radiomic features and key genetic markers related to IDH mutations in glioma.
Analyzed 61 MRI scans from TCIA, divided into training (70%) and validation (30%) sets.
Used LASSO regression for feature selection on 1,037 radiomic features extracted from manually delineated ROIs.
Validated findings with Western blotting and single-cell RNA sequencing to assess protein expression and cellular localization of key genes.
A model using nine radiomic features achieved strong predictive performance for IDH mutation status.
Univariate and multivariate Cox regression confirmed that selected features predict glioma prognosis.
Differential analysis unveiled eight key genes associated with glioma development and IDH mutations, showing varied expression across tumor subpopulations.

Cite This Study

Zhong et al. (2026) studied this question.

synapsesocial.com/papers/6a3a223b111626ef22ab6ecb https://doi.org/10.1186/s12935-026-04384-2

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial investigates MRI features and gene expression for predicting IDH mutations and glioma prognosis, indicating potential for personalized treatment.

Integrating MRI radiomics and transcriptomics to predict IDH mutation status and prognosis in glioma

Discussion

Member takes

Implication

Key Points

Cite This Study

Integrating MRI radiomics and transcriptomics to predict IDH mutation status and prognosis in glioma

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider