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June 23, 2026Breast CancerOpen Access

Prognostic impact of progesterone receptor status in patients with breast cancer and isolated locoregional recurrence

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Authors

TMTakeshi MurataHKHiraku KumamaruMYMasayuki Yoshida

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Overview

Randomized trial assesses prognostic impact of progesterone receptor status in ER+/HER2- breast cancer, suggesting tailored treatment strategies.

Key Points

  • To determine the prognostic impact of progesterone receptor status on outcomes in patients with isolated locoregional recurrence of breast cancer.
  • Utilized data from the Japanese National Clinical Database (2004–2015) involving 1,625 patients with ER+/HER2- ILRR.
  • Compared overall survival and breast cancer-specific survival among three groups based on PR status using Kaplan–Meier method and log-rank test.
  • Defined positive ER and PR status based on immunohistochemistry staining in tumor cells.
  • Patients with PR- ILRR showed significantly worse overall survival and breast cancer-specific survival compared to those with PR+ ILRR.
  • Factors linked to worse outcomes included lymph node metastasis, shorter disease-free interval, and no surgery for ILRR tumors.
  • Emphasized PR-negativity as an independent poor prognostic factor after isolated locoregional recurrence.

Cite This Study

Murata et al. (2026) studied this question.

synapsesocial.com/papers/6a3a225d111626ef22ab6f8chttps://doi.org/10.1007/s12282-026-01882-z
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