Key result
Insulin signaling in the heart, primarily via the PI3K/Akt pathway, regulates substrate utilization and is altered in pathological conditions like type-2 diabetes and myocardial ischemia.
Design
Review
Authors
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May identify cardiac insulin signaling targets in diabetes and ischemia; leaves open whether modulation improves outcomes in patients.
This review summarizes the molecular signaling elements involved in insulin action in the heart and vasculature under physiological, pathological, and therapeutic conditions.
Bertrand et al. (2008) conducted a review in Type-2 diabetes, myocardial ischaemia, and cardiac hypertrophy. Insulin signalling was evaluated. Insulin signaling in the heart, primarily via the PI3K/Akt pathway, regulates substrate utilization and is altered in pathological conditions like type-2 diabetes and myocardial ischemia.
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