Decreased ascending aortic distensibility was associated with increased all-cause mortality (HR 2.7, p=0.008) and a 2-fold higher risk of hard CVD events.
Cohort (n=3,675)
Does decreased ascending aortic distensibility predict all-cause mortality and hard cardiovascular events in individuals without overt cardiovascular disease?
Decreased proximal aortic distensibility measured by MRI independently predicts all-cause mortality and hard cardiovascular events in individuals without overt CVD, potentially aiding risk stratification.
Hazard Ratio: 2.7
p-value: p=0.008
BACKGROUND: The predictive value of ascending aortic distensibility (AAD) for mortality and hard cardiovascular disease (CVD) events has not been fully established. OBJECTIVES: This study sought to assess the utility of AAD to predict mortality and incident CVD events beyond conventional risk factors in MESA (Multi-Ethnic Study of Atherosclerosis). METHODS: AAD was measured with magnetic resonance imaging at baseline in 3,675 MESA participants free of overt CVD. Cox proportional hazards regression was used to evaluate risk of death, heart failure (HF), and incident CVD in relation to AAD, CVD risk factors, indexes of subclinical atherosclerosis, and Framingham risk score. RESULTS: There were 246 deaths, 171 hard CVD events (myocardial infarction, resuscitated cardiac arrest, stroke and CV death), and 88 HF events over a median 8.5-year follow-up. Decreased AAD was associated with increased all-cause mortality with a hazard ratio (HR) for the first versus fifth quintile of AAD of 2.7 (p = 0.008) independent of age, sex, ethnicity, other CVD risk factors, and indexes of subclinical atherosclerosis. Overall, patients with the lowest AAD had an independent 2-fold higher risk of hard CVD events. Decreased AAD was associated with CV events in low to intermediate- CVD risk individuals with an HR for the first quintile of AAD of 5.3 (p = 0.03) as well as with incident HF but not after full adjustment. CONCLUSIONS: Decreased proximal aorta distensibility significantly predicted all-cause mortality and hard CV events among individuals without overt CVD. AAD may help refine risk stratification, especially among asymptomatic, low- to intermediate-risk individuals.
Redheuil et al. (Mon,) conducted a cohort in Free of overt cardiovascular disease (n=3,675). Decreased ascending aortic distensibility vs. Higher ascending aortic distensibility (fifth quintile) was evaluated on All-cause mortality (HR 2.7, p=0.008). Decreased ascending aortic distensibility was associated with increased all-cause mortality (HR 2.7, p=0.008) and a 2-fold higher risk of hard CVD events.