Key result
Decreased ascending aortic distensibility linked to ~170% higher all-cause mortality and more CVD events.
Why the study?
The predictive value of ascending aortic distensibility for mortality and hard cardiovascular disease events had not been fully established.
Does decreased ascending aortic distensibility predict all-cause mortality and hard cardiovascular events in individuals without overt cardiovascular disease?
Cohort (n=3,675)
Does decreased ascending aortic distensibility predict all-cause mortality and hard cardiovascular events in individuals without overt cardiovascular disease?
Hazard Ratio: 2.7
p-value: p=0.008
Decreased proximal aortic distensibility measured by MRI independently predicts all-cause mortality and hard cardiovascular events in individuals without overt CVD, potentially aiding risk stratification.
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May refine primary prevention risk models; leaves open whether measurement alters decisions or outcomes.
Redheuil et al. (2014) conducted a cohort in Free of overt cardiovascular disease (n=3,675). Decreased ascending aortic distensibility vs. Higher ascending aortic distensibility (fifth quintile) was evaluated on All-cause mortality (HR 2.7, p=0.008). Decreased ascending aortic distensibility was associated with increased all-cause mortality (HR 2.7, p=0.008) and a 2-fold higher risk of hard CVD events.
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