Key result
CPET increases serum amylase post-effort, but shows no significant effect on salivary amylase levels.
Why the study?
Does cardiopulmonary exercise testing induce variations in serum and salivary alpha-amylase levels that correlate with echocardiographic and functional exercise parameters in young male professional football players?
Observational (n=19)
Open-label
No
Does cardiopulmonary exercise testing induce variations in serum and salivary alpha-amylase levels that correlate with echocardiographic and functional exercise parameters in young male professional football players?
In young professional football players, serum and salivary alpha-amylase levels correlate with certain cardiopulmonary exercise parameters and reflect acute autonomic and metabolic adaptations to exertion, but non-invasive salivary amylase measurements do not correlate with and cannot replace serum testing.
Answers are grounded in this paper and cite their sources.
Serum amylase rise post-CPET may mark acute stress in athletes; leaves open salivary amylase as non-invasive surrogate.
Background and Objectives: During intense bouts of physical activity, the body of athletes is subjected to stress and sometimes this can lead to adverse events such as injuries or more severe organ dysfunction, like sudden cardiac death. Several markers are being studied to properly assess the level of physical stress that exercises have on the body and one of them is amylase. Materials and Methods: We evaluated 19 licensed football players using basic cardiovascular procedures, i.e., resting 12-lead electrocardiogram (ECG) and trans-thoracic echocardiography (TTE) and performing a cardiopulmonary exercise testing (CPET). Resting (T0) serum and salivary amylase levels were measured, as were immediately post-effort (T1) serum values and 10 min (T2) and 30 min post-CPET (T3) salivary values. Results: Both serum and salivary levels showed correlations with several TTE and CPET parameters. Only T2 salivary amylase levels did not show any correlations with the other parameters, while also no correlations could be established between serum and salivary determinations. Conclusions: Serum and salivary amylase determinations show potential in athlete evaluation even from a cardiovascular risk standpoint since they displayed several correlations with both TTE and CPET parameters, but as part of a more complex protocol. Salivary determinations cannot fully substitute serum measurements. Further studies on larger groups are required.
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Honceriu et al. (2026) conducted an observational in Cardiovascular and physiological stress response to exercise in professional football players (n=19). Cardiopulmonary exercise testing (CPET) vs. Resting baseline (T0) was evaluated on Variations in serum alpha-amylase from rest (T0) to immediately post-effort (T1) and salivary alpha-amylase from rest (T0) to 10 min (T2) and 30 min (T3) post-effort (p=0.025). Cardiopulmonary exercise testing significantly increased serum amylase immediately post-effort (p=0.025), while salivary amylase changes were non-significant and did not correlate with serum levels.
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