Lifestyle interventions, including exercise training and calorie restriction, are effective therapeutic strategies for improving exercise capacity and quality of life in patients with stable HFpEF.
Lifestyle modifications, including diet and exercise, are crucial for managing cardiometabolic HFpEF by improving exercise capacity, physical function, and quality of life.
Heart failure (HF) with preserved ejection fraction (HFpEF) is increasingly prevalent and now recognized as a systemic syndrome with diverse clinical phenotypes and multiorgan involvement. The predominant clinical phenotype has evolved from patients with isolated hypertensive heart disease to individuals with cardiometabolic (CM) abnormalities obesity, insulin resistance, increased waist circumference (a surrogate for visceral adiposity), dyslipidemia, type 2 diabetes, and hypertension that result in metabolic alterations leading to CM-HFpEF. Indeed, CM-HFpEF and metabolic dysfunction-associated fatty liver disease are recognized as two sides of the same coin. Chronic systemic inflammation is a defining pathophysiologic feature of CM-HFpEF, with visceral adipose tissue serving as a central driver. In this regard, lifestyle changes, including diet and exercise, are crucial for managing HFpEF. Several recent studies have shown that exercise training (aerobic and resistance combined) with or without calorie restriction is an effective therapeutic management strategy for improving exercise capacity, physical function, and quality of life in patients with clinically stable HFpEF. Also, the pharmacologic interventions that have proven beneficial in HFpEF so far (sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor agonists) are effective due to their metabolic protective effects. In this review, we outline the current available evidence on lifestyle interventions in HFpEF management and therapeutics, discussing their modalities and potential mechanisms.
Yang et al. (Tue,) conducted a review in Cardiometabolic Heart Failure with Preserved Ejection Fraction (HFpEF). Lifestyle modification (diet and exercise) was evaluated. Lifestyle interventions, including exercise training and calorie restriction, are effective therapeutic strategies for improving exercise capacity and quality of life in patients with stable HFpEF.