Amino acid infusion >21 g/day was evaluated for its effect on AKI in 1,816 aortic surgery patients, with an overall AKI and 30-day mortality incidence of 37.8%.
Observational (n=1,816)
Yes
Does a daily amino acid dose of > 21 g during the first 2 postoperative days reduce the incidence of AKI in patients undergoing aortic surgery?
This target trial emulation evaluated the impact of postoperative amino acid infusion on acute kidney injury following aortic surgery, though results are truncated.
Acute kidney injury (AKI) is a common complication after cardiac surgery and is associated with increased mortality. Amino acids may improve renal perfusion, but their effect in patients undergoing aortic surgery remains unclear. We used the Aortic Surgery Database of the Shanghai Hospital Development Center to emulate a target trial. Patients were classified to one of two exposure strategies: receiving a daily amino acid dose of > 21 g during the first 2 postoperative days, or not receiving amino acid therapy above this threshold. Overlap weighting was used to balance covariates and emulate randomized assignment. The primary outcome was the incidence of AKI. Secondary outcomes included AKI stage, renal replacement therapy, hospital stay, in-hospital mortality, and 30-day mortality. Overall, 1,816 patients were included in the study. The incidence of AKI and 30-day mortality was 37.8% (
Wang et al. (Tue,) conducted a observational in Acute kidney injury after aortic surgery (n=1,816). Amino acid infusion vs. Not receiving amino acid therapy above this threshold was evaluated on Incidence of acute kidney injury (AKI). Amino acid infusion >21 g/day was evaluated for its effect on AKI in 1,816 aortic surgery patients, with an overall AKI and 30-day mortality incidence of 37.8%.