What is the clinical evidence from this study?

Study design: Case Report. Population: Giant left ventricular intracavitary mass (n=2). Intervention: Anticoagulation (enoxaparin and acenocoumarol). Primary outcome: Resolution of left ventricular mass.

What question did this study set out to answer?

Examine the clinical and diagnostic challenges involved in differentiating giant left ventricular thrombi from cardiac tumors in acute presentations.

June 24, 2026CureusOpen Access

Giant Left Ventricular Intracavitary Mass: Diagnostic Challenges in Distinguishing Thrombus From Tumor

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Key result

TTE alone struggles to distinguish giant LV thrombus from tumor, though anticoagulation resolves one case.

Population

2 male patients presenting with giant left ventricular intracavitary masses, one with ischemic…

Design

Case_series

Authors

ABAmal Baicha KAKhaoula Aboubakr NMNajat MouineMilitary Hospital

Discussion

Member takes

Implication

Giant LV masses may cause rapid deterioration; hypothesis-generating cases leave open prospective management trials.

Key Points

Examine the clinical and diagnostic challenges involved in differentiating giant left ventricular thrombi from cardiac tumors in acute presentations.
Reviewed the clinical presentation, imaging evaluations, and management of two patients presenting acutely with giant left ventricular intracavitary masses (N=2).
Evaluated initial transthoracic echocardiography findings, clinical course, and therapeutic response to anticoagulation therapy.
A 70-year-old man with acute bilateral ischemic stroke, ischemic cardiomyopathy, and gastric adenocarcinoma deteriorated rapidly and died before advanced cardiac magnetic resonance imaging could determine mass etiology.
A 52-year-old man presenting with acute coronary syndrome, severe left ventricular dysfunction, and an apical aneurysm achieved complete mass resolution following anticoagulation, confirming an apical thrombus at three-month follow-up.

Study Design

Type

Case Report (n=2)

Multicenter

Structured PICO

Population

2 male patients (ages 70 and 52) presenting with giant left ventricular intracavitary masses, one with ischemic cardiomyopathy and gastric adenocarcinoma, and the other with acute coronary syndrome, severe LV dysfunction, and an apical aneurysm.

Intervention

Diagnostic evaluation (including transthoracic echocardiography) and anticoagulation therapy.

Outcome

Diagnostic clarification and clinical outcome.

This case series highlights the diagnostic challenges of distinguishing giant LV thrombi from tumors using TTE alone and emphasizes the utility of clinical context, disease evolution, and cardiac MRI.

Limitations

Short follow-up period of three months for the second case, limiting assessment of long-term recurrence or late embolic events
Lack of advanced imaging (CMR) or autopsy in the first case due to rapid clinical deterioration
Inability to exclude systemic embolization to other organs in the first case due to lack of additional imaging

Cite This Study

Baicha et al. (2026) conducted a case report in Giant left ventricular intracavitary mass (n=2). Anticoagulation (enoxaparin and acenocoumarol) was evaluated on Resolution of left ventricular mass. In two cases of giant left ventricular intracavitary masses, distinguishing thrombus from tumor using transthoracic echocardiography alone proved challenging, though one case completely resolved with anticoagulation.

synapsesocial.com/papers/6a3c232cd15afadd906f9db2 https://doi.org/10.7759/cureus.111308

Topics

Primary Cardiac Tumors Echocardiography

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Giant Left Ventricular Intracavitary Mass: Diagnostic Challenges in Distinguishing Thrombus From Tumor

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

Topics

Giant Left Ventricular Intracavitary Mass: Diagnostic Challenges in Distinguishing Thrombus From Tumor

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

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