Key result
Severe MAC in TAVI patients predicts ~94% higher all-cause mortality and more pericardial effusions.
Why the study?
Does the presence and severity of mitral annular calcification affect procedural and clinical outcomes in patients undergoing self-expanding TAVI?
Observational (n=245)
Does the presence and severity of mitral annular calcification affect procedural and clinical outcomes in patients undergoing self-expanding TAVI?
Absolute Event Rate: 26.4% vs 12.4%
p-value: p=0.013
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Severe mitral annular calcification and its extension into the left ventricular outflow tract are significant predictors of mortality and the need for permanent pacemaker implantation following self-expanding TAVI.
Şener et al. (2026) conducted an observational in Severe aortic stenosis at intermediate or high surgical risk (n=245). Mitral annular calcification (MAC) vs. No MAC was evaluated on Pericardial effusion (p=0.013). Mitral annular calcification in TAVI patients was associated with higher rates of pericardial effusion (26.4% vs 12.4%), and severe MAC independently predicted all-cause mortality (HR 1.94, p=0.024).
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