Key result
TAVI linked to ~73% lower in-hospital mortality vs SAVR in severe AS.
Why the study?
No data were available comparing in-hospital outcomes after TAVI versus SAVR in patients with severe aortic stenosis in Japan.
Does TAVI improve in-hospital outcomes compared to SAVR in patients with severe aortic stenosis?
Cohort (n=1,714)
Yes
Does TAVI improve in-hospital outcomes compared to SAVR in patients with severe aortic stenosis?
Absolute Risk Reduction: 1.6 (95% CI 0.3–2.9)
Absolute Event Rate: 0.6% vs 2.2%
Absolute Risk Reduction: 1.6%
In a Japanese real-world registry, TAVI was performed in older, higher-risk patients compared to SAVR, but demonstrated a low in-hospital mortality rate comparable to SAVR when excluding dialysis patients, with differing complication profiles.
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Registry data should not change TAVI versus SAVR selection; leaves open comparative effectiveness in Japanese patients pending randomized trials.
Takeji et al. (2023) conducted a cohort in Severe aortic stenosis (n=1,714). Transcatheter aortic valve implantation (TAVI) vs. Surgical aortic valve replacement (SAVR) was evaluated on In-hospital death (ARR 1.6%, 95% CI 0.3-2.9). In a real-world Japanese registry, in-hospital mortality was numerically lower after TAVI compared to SAVR (0.6% vs 2.2%) in patients with severe aortic stenosis.
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