Key result
Four monoclonal antibodies targeting the PRRSV-1 nucleocapsid protein reveal novel linear B-cell epitopes.
The study developed four monoclonal antibodies targeting the PRRSV-1 nucleocapsid protein and identified novel linear B-cell epitopes, which may aid in detecting PRRSV-1 infection.
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May inform PRRSV-1 diagnostic development in swine; leaves open prospective validation before clinical adoption.
Porcine reproductive and respiratory syndrome virus (PRRSV) are responsible for reproductive failure in sows and respiratory diseases in pigs, inflicting significant economic losses worldwide. Due to continuous mutation and recombination, PRRSV exhibit remarkable genetic diversity, necessitating detection methods capable of recognizing PRRSV-2 and/or PRRSV-1 strains. In this study, four monoclonal antibodies (mAbs) targeting the PRRSV-1 nucleocapsid (N) protein were generated, and the precise and novel linear B-cell epitopes were identified as
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Zhang et al. (2026) studied Porcine reproductive and respiratory syndrome virus (PRRSV) infection. Monoclonal antibodies targeting PRRSV-1 nucleocapsid (N) protein was evaluated on Generation of monoclonal antibodies and identification of B-cell epitopes. Four monoclonal antibodies targeting the PRRSV-1 nucleocapsid protein were generated and novel linear B-cell epitopes were identified.
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