40 | Predictive accuracy of anticholinergic burden scales for ecg abnormalities in older adults

Q: What does this research mean for the field?

The Anticholinergic Burden Classification (ABC) scale is the most accurate predictor of overall ECG abnormalities and atrial fibrillation among seven validated anticholinergic burden scales in older adults. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Segreteria SIGOT

doi:10.4081/gc.2026.15791

June 11, 2026Geriatric CareOpen Access

40 | Predictive accuracy of anticholinergic burden scales for ecg abnormalities in older adults

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Why the study?

Which anticholinergic burden scale has the highest accuracy in predicting ECG abnormalities in older adults?

Key Points

This study aims to compare the predictive accuracy of seven anticholinergic burden scales for ECG abnormalities in older adults.
Multicenter prospective study with 292 geriatric patients (mean age 80.7±6.2 years)
Assessment of anticholinergic burden using seven validated scales
Evaluation of ECG findings through ROC curves and multivariate logistic regression.
Pathological ECGs were found in 12.1% of patients.
ABC, ACB, and ADS scales significantly associated with ECG abnormalities and atrial fibrillation.
ABC was identified as the best predictor for overall ECG abnormalities (AUC 0.666; p=0.001) and AF (AUC 0.715; p<0.001).

Structured PICO

Which anticholinergic burden scale has the highest accuracy in predicting ECG abnormalities in older adults?

P

Population

292 older adult patients (mean age 80.7±6.2 years)

I

Intervention

Assessment of anticholinergic burden using seven validated scales (Anticholinergic Activity Scale [AAS], Anticholinergic Burden Classification [ABC], Anticholinergic Cognitive Burden [ACB], Anticholinergic Drug Scale [ADS], Anticholinergic Risk Scale [ARS], Clinician-Rated Anticholinergic Score [CRAS], and Anticholinergic Loading Scale [ACL])

C

Comparator

Comparison among the seven different anticholinergic burden scales

O

Outcome

Predictive accuracy for pathological 12-lead ECG findings (including Atrial Fibrillation and conduction blocks)surrogate

The Anticholinergic Burden Classification (ABC) scale is the most accurate among seven evaluated tools for predicting ECG abnormalities, including atrial fibrillation, in older adults.

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Implication

ABC scale may aid ECG risk stratification in older adults; leaves open prospective validation against other scales.

Abstract

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Discussion

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Cite This Study

Segreteria SIGOT (2026) studied this question.

synapsesocial.com/papers/6a3c234fd15afadd906f9f53 https://doi.org/10.4081/gc.2026.15791

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40 | Predictive accuracy of anticholinergic burden scales for ecg abnormalities in older adults

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

40 | Predictive accuracy of anticholinergic burden scales for ecg abnormalities in older adults

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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