Platelets’ autοⅰmmune antⅰbοdy level as a predⅰсtοr οf malarⅰa severⅰty

Background: Alterations in platelet count and function are frequently observed during malaria infection; however, the underlying mechanisms remain incompletely understood. Immune-mediated platelet destruction has been proposed as a contributing factor to malaria-associated thrombocytopenia. Few studies have investigated the relationship between platelet autoimmune antibody levels and malaria severity. Methods : The 96 chosen malaria patients who came to Almaza Fever Hospital were included in this observational analytical cross-sectional study. The period of recruitment was April 2022–February 2023. The patients in the study were split into three groups based on the severity of their malaria: group 1 consisted of 47 patients with mild malaria, group 2 of 28 patients with intermediate malaria, and group 3 of 21 patients with severe malaria. Results: According to the study's findings, there was no statistically significant difference between the groups' chest x-ray and CT brain results, but there was a highly significant difference between the groups' hepatosplenomegaly by US, with all of the severe group having HSM, 14.3% of the moderate group, and no patients in the mild group. The Glasgow coma score was 14 in the all-severe group and 15 in the other groups, indicating a very statistically significant difference between the groups under study. Given that the group with severe malaria had the lowest mean blood glucose levels compared to the mild and moderate groups, the current study discovered a highly statistically significant difference in blood glucose levels across the groups under investigation upon admission.