Key result
GLP-1 RAs may modulate suicidality and depression via immunometabolic pathways, necessitating personalized psychiatric monitoring.
Requires vigilance for suicidality during GLP-1 RA use; leaves open inflammation as a modifiable therapeutic target.
Keywords dopamine , GABA , ghrelin , GLP-1 RA , inflammation , leptin , suicidality Citation Borovcanin MM and Petrovic I (2026) Suicidality as a potential risk and therapeutic target during widespread GLP-1 receptor agonists use: implications of inflammation . Front. Synaptic Neurosci. 18:1869086. doi: 10.3389/fnsyn.2026.1869086 Received 29 April 2026 Revised 14 May 2026 Accepted 15 May 2026 Published 04 June 2026 Volume 18 - 2026 Edited by Ajeet Kumar , Washington University in St. Louis, United States Reviewed by Kyle Valentino , University of Toronto, Canada Updates Check for updates Copyright © 2026 Borovcanin and Petrovic. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. * Correspondence: Milica M. Borovcanin, milicaborovcanin@yahoo.com Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Borovcanin et al. (2026) conducted an editorial in Type 2 Diabetes Mellitus, Obesity, and Suicidality. GLP-1 receptor agonists was evaluated. GLP-1 receptor agonists may modulate suicidality and depression through immunometabolic pathways and inflammation, necessitating personalized psychiatric monitoring during treatment.
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