Figure 1. Reversible Transverse Aortic Constriction Methods and Results (A) Schematic and representative images of refined transverse aortic constriction (TAC), minimally invasive de-banding (deTAC), and Mooring hitch and experimental timeline. Black arrows indicate suture traction; scissor icon denotes incised tissue. Representative B-mode images of the transverse aorta (dotted outline) from the same animal at each timepoint. Scale bars represent 1 mm. Peak aortic velocities measured at constriction site by pulsed-wave Doppler. Ejection fraction measured from left ventricular long-axis 2-dimensional B-mode images. (B) Relative wall thickness (2∗[wall thickness/diameter]) measured from 2-dimensional M-mode ultrasound. LV mass measured via 4-dimensional ultrasound. Quantification of myocyte cross-sectional area from WGA staining of the left ventricle. qPCR for Nppb normalized to Gapdh and Actb (2-ΔΔCt). Quantification of Collagen type I+ area over total area in the left ventricle. Statistical analyses were performed in GraphPad Prism 10 with significance set at P < 0.05. Normality was assessed using the Shapiro-Wilk test. Ejection fraction, left ventricular mass was analyzed using repeated…
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