Editor Note to article entitled “Mdivi-1, a mitochondrial fission inhibitor, reduces angiotensin-II- induced hypertension by mediating VSMC phenotypic switch” Biomed. Pharmacother. 140 (2021) 111689

Key Points

• The aim is to discuss the role of Mdivi-1 in mitigating hypertension by influencing vascular smooth muscle cells (VSMCs).
• Reviewed existing findings on Mdivi-1's impact on mitochondrial fission and regulation in VSMCs.
• Analyzed its effects on angiotensin-II induced hypertension.
• Mdivi-1 effectively reduced hypertension induced by angiotensin-II.
• It promoted a phenotypic switch in VSMCs, suggesting a novel therapeutic pathway.