83068 | Leaflet Modification for Redo-TAVR: Impact of Valve Type, Expansion and Failure Mode - A Bench Study

David Meier; Lucca Loretz; Ed Quine; Alison Kane; David Elison; Brooke MacLeod; Colin Jamieson; Sheryl Munshan; Andrew Chatfield; Thomas Puehler; Nina Pommert; Gilbert Tang; Vasilis Babaliaros; Alessandro Beneduce; Arif Khokhar; James McCabe; John Webb; Ole De Backer; David Wood; Shinichi Fukuhara; Jaffar Khan; Stephanie Sellers

doi:10.1016/j.shj.2026.100951

Key result

Bench testing clarifies how constraint, sizing, and flow dictate leaflet modification efficacy in redo-TAVR.

Why the study?

What are the effects of valve constraint, redo-TAVR sizing, flow, and valve pathology on the efficacy of leaflet modification in redo-TAVR?

Key Points

To evaluate how valve constraint, sizing, hemodynamic flow, and valve pathology impact the efficacy of leaflet modification during redo transcatheter aortic valve replacement.
Conducted a controlled benchtop simulation examining leaflet modification across diverse transcatheter heart valve configurations.
Evaluated the mechanical impact of valve constraint, redo valve sizing, flow rates, and specific modes of valve failure on procedural performance.
Identified valve constraint and transcatheter valve sizing as determinants of leaflet modification efficacy in redo procedures.
Demonstrated that fluid flow conditions and initial valve failure modes influence the mechanical success of leaflet modification.

Structured PICO

What are the effects of valve constraint, redo-TAVR sizing, flow, and valve pathology on the efficacy of leaflet modification in redo-TAVR?

P

Population

Bench study models for redo-TAVR

I

Intervention

Leaflet modification (LM)

O

Outcome

Efficacy of leaflet modification (effects of valve constraint, redo-TAVR sizing, flow, and valve pathology)surrogate

Implication

This bench study investigates the technical and anatomical factors impacting the efficacy of leaflet modification during redo-TAVR procedures.

Abstract

Leaflet modification (LM) is of interest in redo-TAVR. However, factors impacting efficacy of LM are poorly understood. Therefore, we investigated the effects of valve constraint, redo-TAVR sizing, flow, and valve pathology on LM.

Discussion

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Cite This Study

Meier et al. (2026) studied this question. Leaflet modification efficacy during redo-TAVR was investigated in a bench model to assess the impact of valve constraint, sizing, flow, and pathology.

synapsesocial.com/papers/6a3c2381d15afadd906fa3ce https://doi.org/10.1016/j.shj.2026.100951

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83068 | Leaflet Modification for Redo-TAVR: Impact of Valve Type, Expansion and Failure Mode - A Bench Study

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

83068 | Leaflet Modification for Redo-TAVR: Impact of Valve Type, Expansion and Failure Mode - A Bench Study

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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