83468 | Elliptical Aortic Root Geometry Modulates Leaflet Dynamics and Calcification Patterns in Transcatheter Aortic Valves: An In-Silico Study

Background: Current in-silico models of transcatheter aortic valves (TAVs) typically assume symmetric expansion and often overlook leaflet dynamics under non-ideal anatomical conditions.The impact of aortic root ellipticity on leaflet mechanics and calcification patterns remains insufficiently characterized.Methods: A high-fidelity 3D computational model of a bioprosthetic TAV was developed with detailed leaflet dynamics and calibrated against in vitro data.The model was deployed in anatomically derived geometries with varying degrees of ellipticity based on medical imaging.Leaflet kinematics during the cardiac cycle were analyzed, and regions of elevated mechanical stress were used to estimate calcification propensity and spatial distribution.Results: Two extreme aortic phenotypes defined by low versus high ellipticity were analyzed.In both models, calcification propensity was consistently higher near suture regions.In near-cylindrical anatomies, stress concentration-and predicted calcification-was localized predominantly at commissural points.In contrast, elliptical anatomies demonstrated a broader distribution of stress across the leaflet surface, with a wider but less focal pattern of predicted calcification.Conclusion: Aortic root ellipticity significantly influences leaflet dynamics and the spatial pattern of calcification in transcatheter valves.These findings highlight the importance of patient-specific anatomy in valve performance and support the use of advanced computational modeling for device optimization and personalized procedural planning.