The 2025 clinical practice guideline for spontaneous isolated superior mesenteric artery dissection issued 19 recommendations, with only a minority supported by high-quality evidence.
This 2025 clinical practice guideline provides 19 evidence-based recommendations for the management of spontaneous isolated superior mesenteric artery dissection, highlighting the need for further high-quality research.
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Spontaneous isolated superior mesenteric artery dissection (SISMAD) is a relatively rare but potentially life-threatening disease. Optimal medical management strategies remain uncertain. Therefore, developing evidence-based clinical practice guidelines is essential to improve treatments of SISMAD. The guideline adopted approaches informed by the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology and the European Society of Cardiology (ESC) grading system. Recommendations were formulated according to the quality of evidence, categorized as high (Level A), moderate (Level B), or low (Level C). After reviewing the literature of eight topics, including clinical presentation, imaging evaluation, classification, medical management strategies, and follow-up, the guide writing committee issued 19 recommendations from currently available evidence. Among the 19 recommendations, only a minority were supported by high-quality evidence, underscoring the urgent need for further well-designed clinical studies and prospective research to refine the management of SISMAD.
Ling et al. (Mon,) reported a other. The 2025 clinical practice guideline for spontaneous isolated superior mesenteric artery dissection issued 19 recommendations, with only a minority supported by high-quality evidence.