Key result
Incorporating objective physiological measurements, individualized hemodynamic targets, and wider biochemical profiling is recommended to strengthen causal inference in mediation analyses of postoperative acute kidney injury.
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This letter highlights methodological considerations for mediation analysis of postoperative acute kidney injury, emphasizing the need for objective physiological measurements and individualized hemodynamic targets.
Dong et al. (2026) conducted a letter in Postoperative Acute Kidney Injury. Incorporating objective physiological measurements, individualized hemodynamic targets, and wider biochemical profiling is recommended to strengthen causal inference in mediation analyses of postoperative acute kidney injury.
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